Question Marks showing in Big Sur applications:
The Extensis Support team has received several reports where fonts in multiple applications where fonts would appear with (or display) Question Marks or otherwise known as the Last Resort Font.
Other reports are informing us that fonts will not activate using the auto-activation plug-ins when using Adobe CC applications in macOS Big Sur (macOS 11) using common fonts such as Helvetica.
In most instances, we have noticed these issues being caused by font conflicts within the Operating Systems Fonts and Suitcase Fusion fonts trying to activate. These issues are typically related to fonts being active when using Suitcase fusion and conflicting with fonts already being used by the system or trying to activate causing the fonts to conflict.
For Question Marks being displayed in your applications, use the link below to troubleshoot:
NOTE - Step 1 and/or 2 in the link above usually resolve the issue.